19 Eylül 2010 Pazar

Gregor Johann Mendel

Gregor Johann Mendel (July 20, 1822[1] – January 6, 1884) was an Augustinian priest and scientist, who gained posthumous fame as the figurehead of the new science of genetics for his study of the inheritance of certain traits in pea plants. Mendel showed that the inheritance of these traits follows particular laws, which were later named after him. The significance of Mendel's work was not recognized until the turn of the 20th century. The independent rediscovery of these laws formed the foundation of the modern science of genetics.[2]

Biography

Mendel was born into an ethnic German family in Heinzendorf bei Odrau, Austrian Silesia, Austrian Empire (now Hynčice, Czech Republic), and was baptized two days later. He was the son of Anton and Rosine Mendel, and had one older sister and one younger. They lived and worked on a farm which had been owned by the Mendel family for at least 130 years.[3] During his childhood, Mendel worked as a gardener, studied beekeeping, and as a young man attended the Philosophical Institute in Olomouc in 1840–1843. Upon recommendation of his physics teacher Friedrich Franz, he entered the Augustinian Abbey of St Thomas in Brno in 1843. Born Johann Mendel, he took the name Gregor upon entering monastic life. In 1851 he was sent to the University of Vienna to study under the sponsorship of Abbot C. F. Napp. At Vienna, his professor of physics was Christian Doppler.[4] Mendel returned to his abbey in 1853 as a teacher, principally of physics, and by 1867, he had replaced Napp as abbot of the monastery.[5]

Besides his work on plant breeding while at St Thomas's Abbey, Mendel also bred bees in a bee house that was built for him, using bee hives that he designed.[6] He also studied astronomy and meteorology[5], founding the 'Austrian Meteorological Society' in 1865.[4] The majority of his published works were related to meteorology.[4]
Experiments on plant hybridization

Gregor Mendel, who is known as the "father of modern genetics", was inspired by both his professors at university and his colleagues at the monastery to study variation in plants, and he conducted his study in the monastery's two hectare[7] experimental garden, which was originally planted by the abbot Napp in 1830.[5] Between 1856 and 1863 Mendel cultivated and tested some 29,000 pea plants (i.e., Pisum sativum). This study showed that one in four pea plants had purebred recessive alleles, two out of four were hybrid and one out of four were purebred dominant. His experiments led him to make two generalizations, the Law of Segregation and the Law of Independent Assortment, which later became known as Mendel's Laws of Inheritance.

Mendel did read his paper, Experiments on Plant Hybridization, at two meetings of the Natural History Society of Brünn in Moravia in 1865. When Mendel's paper was published in 1866 in Proceedings of the Natural History Society of Brünn,[8] it had little impact and was cited about three times over the next thirty-five years. (Notably, Charles Darwin was unaware of Mendel's paper, according to Jacob Bronowski's The Ascent of Man.) His paper was criticized at the time, but is now considered a seminal work.
Life after the pea experiments

After Mendel completed his work with peas, he turned to experimenting with honeybees, in order to extend his work to animals. He produced a hybrid strain (so vicious they were destroyed), but failed to generate a clear picture of their heredity because of the difficulties in controlling mating behaviours of queen bees. He also described novel plant species, and these are denoted with the botanical author abbreviation "Mendel".

After he was elevated as abbot in 1868, his scientific work largely ended as Mendel became consumed with his increased administrative responsibilities, especially a dispute with the civil government over their attempt to impose special taxes on religious institutions.[9] At first Mendel's work was rejected, and it was not widely accepted until after he died. At that time most biologists held the idea of blending inheritance, and Charles Darwin's efforts to explain inheritance through a theory of pangenesis were unsuccessful. Mendel's ideas were rediscovered in the early twentieth century, and in the 1930s and 1940s the modern synthesis combined Mendelian genetics with Darwin's theory of natural selection.

Mendel died on January 6, 1884, at age 61, in Brno, Moravia, Austria-Hungary (now Czech Republic), from chronic nephritis. Czech composer Leoš Janáček played the organ at his funeral. After his death the succeeding abbot burned all papers in Mendel's collection, to mark an end to the disputes over taxation.[10]
Rediscovery of Mendel's work
Dominant and recessive phenotypes. (1) Parental generation. (2) F1 generation. (3) F2 generation.

It was not until the early 20th century that the importance of his ideas was realized. By 1900, research aimed at finding a successful theory of discontinuous inheritance rather than blending inheritance led to independent duplication of his work by Hugo de Vries and Carl Correns, and the rediscovery of Mendel's writings and laws. Both acknowledged Mendel's priority, and it is thought probable that de Vries did not understand the results he had found until after reading Mendel.[2] Though Erich von Tschermak was originally also credited with rediscovery, this is no longer accepted because he did not understand Mendel's laws.[11] Though de Vries later lost interest in Mendelism, other biologists started to establish genetics as a science.[2]

Mendel's results were quickly replicated, and genetic linkage quickly worked out. Biologists flocked to the theory, even though it was not yet applicable to many phenomena, it sought to give a genotypic understanding of heredity which they felt was lacking in previous studies of heredity which focused on phenotypic approaches. Most prominent of these latter approaches was the biometric school of Karl Pearson and W.F.R. Weldon, which was based heavily on statistical studies of phenotype variation. The strongest opposition to this school came from William Bateson, who perhaps did the most in the early days of publicising the benefits of Mendel's theory (the word "genetics", and much of the discipline's other terminology, originated with Bateson). This debate between the biometricians and the Mendelians was extremely vigorous in the first two decades of the twentieth century, with the biometricians claiming statistical and mathematical rigor, whereas the Mendelians claimed a better understanding of biology. In the end, the two approaches were combined as the modern synthesis of evolutionary biology, especially by work conducted by R. A. Fisher as early as 1918.

Mendel's experimental results have later been the object of considerable dispute.[10] Fisher analyzed the results of the F2 (second filial) ratio and found them to be implausibly close to the exact ratio of 3 to 1.[12] Only a few would accuse Mendel of scientific malpractice or call it a scientific fraud—reproduction of his experiments has demonstrated the validity of his hypothesis—however, the results have continued to be a mystery for many, though it is often cited as an example of confirmation bias. This might arise if he detected an approximate 3 to 1 ratio early in his experiments with a small sample size, and continued collecting more data until the results conformed more nearly to an exact ratio. It is sometimes suggested that he may have censored his results, and that his seven traits each occur on a separate chromosome pair, an extremely unlikely occurrence if they were chosen at random. In fact, the genes Mendel studied occurred in only four linkage groups, and only one gene pair (out of 21 possible) is close enough to show deviation from independent assortment; this is not a pair that Mendel studied. Some recent researchers have suggested that Fisher's criticisms of Mendel's work may have been exaggerated

Terry Fox

For other uses, see Terry Fox (disambiguation).
Terry Fox
A young man with short, curly hair and an artificial right leg runs down a street. He wears shorts and a T-shirt that reads "Marathon of Hope"
Terry Fox in Toronto during his Marathon of Hope cross-country run (July 1980).
Born Terrance Stanley Fox
July 28, 1958(1958-07-28)
Winnipeg, Manitoba, Canada
Died June 28, 1981 (aged 22)
Port Coquitlam, British Columbia, Canada
Cause of death Metastatic osteosarcoma
Education Simon Fraser University
Known for Marathon of Hope
Title Companion of the Order of Canada

Terrance Stanley "Terry" Fox, CC, OD (July 28, 1958 – June 28, 1981) was a Canadian humanitarian and an athlete. In 1980, with one leg having been amputated, he embarked on a cross-Canada run to raise money and awareness for cancer research. Although the spread of his cancer eventually forced him to end his quest after 143 days and 5,373 kilometres (3,339 mi), and ultimately cost him his life, his efforts resulted in a lasting, worldwide legacy. The annual Terry Fox Run, first held in 1981, has grown to involve millions of participants in over 60 countries and is now the world's largest one-day fundraiser for cancer research; over C$500 million has been raised in his name.

Fox was a distance runner and basketball player for his Port Coquitlam, British Columbia, high school and Simon Fraser University. His right leg was amputated in 1977 after he was diagnosed with osteosarcoma, though he continued to run using an artificial leg. He also played wheelchair basketball in Vancouver, winning three national championships.

In 1980, he began the Marathon of Hope, a cross-country run to raise money for cancer research. Fox hoped to raise one dollar for each of Canada's 24 million people. He started with little fanfare from St. John's, Newfoundland, in April and ran the equivalent of a full marathon every day. Fox had become a national star by the time he reached Ontario; he made numerous public appearances with businessmen, athletes, and politicians in his efforts to raise money. He was forced to end his run outside of Thunder Bay when the cancer spread to his lungs. His hopes of overcoming the disease and completing his marathon ended when he died nine months later.

Fox was the youngest person ever named a Companion of the Order of Canada, the highest rank of the nation's highest civilian award. He won the 1980 Lou Marsh Award as the nation's top sportsman and was named Canada's Newsmaker of the Year in both 1980 and 1981. Considered a national hero, he has had many buildings, roads and parks named in his honour across the country.

18 Eylül 2010 Cumartesi

Sales Management

Sales management is attainment of an organization's sales goals in an effective & efficient manner through planning, staffing, training, leading & controlling organizational resources. Revenue, sales, and sources of funds fuel organizations and the management of that process is the most important function.

Sales Planning

An essential sales leadership role is to establish a sense of purpose or vision and clear direction to get there. A key element of a business’ strategic 12-month plan is to answer the question: “Where will all the sales come from?” The sales plan is not a guesstimate. It takes its direction from the marketing strategy and is based on thorough research and a considered positioning of the company within the market place..

Sales planning involves predicting demand for the product and demand on the sales assets (machines, people, or a combination of both). Failure to plan always means lost sales. Planning insures that when a consumer wishes to purchase the product, the product is available, but it also means opportunities for additional sales are presented and the sales assets are available to exploit these opportunities. Planning should allow for meeting increasing customer demand for more products, services and/or customization as the business is growing, but also react quickly when demand decreases. Sales planning improves efficiency and decreases unfocused and uncoordinated activity within the sales process.
[edit] Sales Reporting

The sales reporting includes the key performance indicators of the sales force.

The Key Performance Indicators indicate whether or not the sales process is being operated effectively and achieves the results as set forth in sales planning. It should enable the sales managers to take timely corrective action deviate from projected values. It also allows senior management to evaluate the sales manager.

More "results related" than "process related" are information regarding the sales funnel and the hit rate.

Sales reporting can provide metrics for sales management compensation. Rewarding the best managers without accurate and reliable sales reports is not objective.

Also, sales reports are made for internal use for top management. If other divisions’ compensation plan depends on final results, it is needed to present results of sales department’s work to other departments.

Finally, sales reports are required for investors, partners and government, so the sales management system should have advanced reporting capabilities to satisfy the needs of different stakeholders.

Personal Finance

Personal finance is the application of the principles of finance to the monetary decisions of an individual or family unit. It addresses the ways in which individuals or families obtain, budget, save, and spend monetary resources over time, taking into account various financial risks and future life events. Components of personal finance might include checking and savings accounts, credit cards and consumer loans, investments in the stock market, retirement plans, social security benefits, insurance policies, and income tax management.

Personal financial planning

A key component of personal finance is financial planning, a dynamic process that requires regular monitoring and reevaluation. In general, it has five steps:

1. Assessment: One's personal financial situation can be assessed by compiling simplified versions of financial balance sheets and income statements. A personal balance sheet lists the values of personal assets (e.g., car, house, clothes, stocks, bank account), along with personal liabilities (e.g., credit card debt, bank loan, mortgage). A personal income statement lists personal income and expenses.
2. Setting goals: Two examples are "retire at age 65 with a personal net worth of $1,000,000" and "buy a house in 3 years paying a monthly mortgage servicing cost that is no more than 25% of my gross income". It is not uncommon to have several goals, some short term and some long term. Setting financial goals helps direct financial planning.
3. Creating a plan: The financial plan details how to accomplish your goals. It could include, for example, reducing unnecessary expenses, increasing one's employment income, or investing in the stock market.
4. Execution: Execution of one's personal financial plan often requires discipline and perseverance. Many people obtain assistance from professionals such as accountants, financial planners, investment advisers, and lawyers.
5. Monitoring and reassessment: As time passes, one's personal financial plan must be monitored for possible adjustments or reassessments.

Typical goals most adults have are paying off credit card and or student loan debt, retirement, college costs for children, medical expenses, and estate planning.[citation needed]

The six key areas of personal financial planning, as suggested by the Financial Planning Standards Board, are:

1 - Financial Position: this area is concerned with understanding the personal resources available by examining net worth and household cash flow. Net worth is a person's balance sheet, calculated by adding up all assets under that person's control, minus all liabilities of the household, at one point in time. Household cash flow totals up all the expected sources of income within a year, minus all expected expenses within the same year. From this analysis, the financial planner can determine to what degree and in what time the personal goals can be accomplished.

2 - Adequate Protection: the analysis of how to protect a household from unforeseen risks. These risks can be divided into liability, property, death, disability, health and long term care. Some of these risks may be self-insurable, while most will require the purchase of an insurance contract. Determining how much insurance to get, at the most cost effective terms requires knowledge of the market for personal insurance. Business owners, professionals, athletes and entertainers require specialized insurance professionals to adequately protect themselves. Since insurance also enjoys some tax benefits, utilizing insurance investment products may be a critical piece of the overall investment planning.

3 - Tax Planning: typically the income tax is the single largest expense in a household. Managing taxes is not a question of if you will pay taxes, but when and how much. Government gives many incentives in the form of tax deductions and credits, which can be used to reduce the lifetime tax burden. Most modern governments use a progressive tax. Typically, as your income grows, you pay a higher marginal rate of tax. Understanding how to take advantage of the myriad tax breaks when planning your personal finances can make a significant impact upon your success.

4 - Investment and Accumulation Goals: planning how to accumulate enough money to acquire items with a high price is what most people consider to be financial planning. The major reasons to accumulate assets is for the following: a - purchasing a house b - purchasing a car c - starting a business d - paying for education expenses e - accumulating money for retirement, to generate a stream of income to cover lifestyle expenses.

Achieving these goals requires projecting what they will cost, and when you need to withdraw funds. A major risk to the household in achieving their accumulation goal is the rate of price increases over time, or inflation. Using net present value calculators, the financial planner will suggest a combination of asset earmarking and regular savings to be invested in a variety of investments. In order to overcome the rate of inflation, the investment portfolio has to get a higher rate of return, which typically will subject the portfolio to a number of risks. Managing these portfolio risks is most often accomplished using asset allocation, which seeks to diversify investment risk and opportunity. This asset allocation will prescribe a percentage allocation to be invested in stocks, bonds, cash and alternative investments. The allocation should also take into consideration the personal risk profile of every investor, since risk attitudes vary from person to person.

5 - Retirement Planning: retirement planning is the process of understanding how much it costs to live at retirement, and coming up with a plan to distribute assets to meet any income shortfall.

6 - Estate Planning: involves planning for the disposition of your asset when you die. Typically, there is a tax due to the state or federal government at your death. Avoiding these taxes means that more of your assets will be distributed to your heirs. You can leave your assets to family, friends or charitable groups.

Asbestos

For other uses, see Asbestos (disambiguation).
Fibrous asbestos on muscovite
Asbestos
Asbestos
Blue asbestos (crocidolite) from Wittenoom, Western Australia. The ruler is 1 cm.
Blue asbestos showing the fibrous nature of the mineral

Asbestos (from Greek ἄσβεστος meaning "unquenchable" or "inextinguishable") is a set of six naturally occurring silicate minerals exploited commercially for their desirable physical properties. They all have in common their asbestiform habit, long, (1:20) thin fibrous crystals. The inhalation of asbestos fibers can cause serious illnesses, including malignant lung cancer, mesothelioma (a formerly rare cancer strongly associated with exposure to asbestos and fiber glass.), and asbestosis (a type of pneumoconiosis). Long term exposure to asbestos is more likely to cause health problems, as asbestos exists in the ambient air at low levels, which itself does not cause health problems.[1] The European Union has banned all use of asbestos[2] and extraction, manufacture and processing of asbestos products.[3]

Asbestos became increasingly popular among manufacturers and builders in the late 19th century because of its sound absorption, average tensile strength, and its resistance to heat, electrical and chemical damage. When asbestos is used for its resistance to fire or heat, the fibers are often mixed with cement or woven into fabric or mats. Asbestos was used in some products for its heat resistance, and in the past was used on electric oven and hotplate wiring for its electrical insulation at elevated temperature, and in buildings for its flame-retardant and insulating properties, tensile strength, flexibility, and resistance to chemicals.

Home Improvement

Types of home improvement

While it most often refers to building projects that alter the structure of an existing home, home renovation can include improvements to lawns and gardens and outbuildings like gazebos and garages.

Home improvement projects generally have one or more of the following goals:
[edit] Beautification and added features

* Wallpapering and painting walls or installing wood panelling.
* Adding new flooring such as carpets, tiling, linoleum, wood flooring, or solid hardwood flooring.
* Upgrading cabinets, fixtures, and sinks in the kitchen and bathroom.
* Replacing siding and windows
* Improving the backyard with sliding doors, wooden patio decks, patio gardens, jacuzzis, swimming pools, and fencing.

[edit] Comfort

* Upgrading heating, ventilation and air conditioning systems (HVAC)
* Increasing the capacity of plumbing and electrical systems.
* Waterproofing basements.
* Soundproofing rooms, especially bedrooms and baths.

[edit] Maintenance and repair

Maintenance projects can include:

* Roof tear-off and replacement.
* Concrete and masonry repairs to the foundation and chimney.
* Repairing plumbing and electrical systems.

[edit] Additional space

Additional living space may be added by:

* Turning marginal areas into livable spaces such as turning basements into recrooms, home theaters, or home offices – or attics into spare bedrooms.
* Extending one's house with rooms added to the side of one's home or, sometimes, extra levels to the original roof.

[edit] Saving energy

Homeowners may reduce utility costs with:

* Energy-efficient Thermal insulation, Window, and lighting.
* Renewable energy with biomass pellet stoves, wood-burning stoves, solar panels, wind turbines, Programmable thermostats,[1] and geothermal exchange heat pumps (see autonomous building)

[edit] Safety and preparedness

Emergency preparedness safety measures such as:

* Home fire and burglar alarm systems.
* Fire sprinkler systems to protect homes from fires
* Security doors, windows, and shutters.
* Storm cellars as protection from tornadoes and hurricanes.
* Bomb shelters especially during the 1950s as protection from nuclear war.
* Backup generators for providing power during power outages

[edit] Professional versus do-it-yourself

There are three main approaches to managing a home improvement project: hiring a general contractor, directly hiring specialized contractors, or doing the work oneself.

A general contractor oversees a home improvement project that involves multiple trades. A general contractor acts as project manager, providing access to the site, removing debris, coordinating work schedules, and performing some aspects of the work.

35% of homeowners, according to the Remodeling Sentiment Report bypass the general contractor, and hire tradesmen themselves, including plumbers, electricians and roofers.

Another strategy is to "do it yourself" (DIY). 67% of homeowners report they will do some work themselves when they remodel according to the Remodeling Sentiment Report. Several major American retailers, such as Home Depot and Lowes, specialize in selling materials and tools for DIY home improvement. These stores host classes and carry numerous books to teach customers how to do the work themselves. DIY websites also provide information.
[edit] Home improvement industry

Home or residential renovation is a $300 billion industry in the United States,[2] and a $48 billion industry in Canada.[3] The average cost per project is $3,000 in the United States and $11,000–15,000 in Canada.[4]

There are several types of companies that contribute to the booming renovation industry. Supply businesses such as Home Depot, Lowes, Menards and Rona Lansing provide all the materials and tools necessary to facilitate home renovations. Many online companies and home improvement websites offer tips, guidelines and trends to give homeowners ideas for design and décor.
[edit] Associations

Playing a critical role are the professional associations created to represent the architects, architectural technologists, interior designers and skilled trades that provide specialized services to homeowners. These associations provide credibility, trade guidelines and useful information to help homeowners learn more about the trades they are about to hire.[citation needed]

Associations include:

* Association of Registered Interior Designers of Ontario
* The American Institute of Architects

[edit] Renovation Contractors

Perhaps the most important or visible professionals in the renovation industry are renovation contractors or skilled trades. These are the builders that have specialized credentials, licensing and experience to perform renovation services in specific municipalities. While there is a fairly large ‘grey market’ of unlicensed companies, there are those that have membership in a reputable association or are accredited by a professional organization.
[edit] Home improvement on television

Home improvement was launched on television in 1979 with the premiere of This Old House starring Bob Vila on PBS.

The sitcom Home Improvement used the home improvement theme for comedic purposes.

American cable channel HGTV features many do-it-yourself shows, as does sister channel DIY Network and the competing Discovery Home.

Email Marketing

E-mail marketing is a form of direct marketing which uses electronic mail as a means of communicating commercial or fundraising messages to an audience. In its broadest sense, every e-mail sent to a potential or current customer could be considered e-mail marketing. However, the term is usually used to refer to:

* sending e-mails with the purpose of enhancing the relationship of a merchant with its current or previous customers, to encourage customer loyalty and repeat business,
* sending e-mails with the purpose of acquiring new customers or convincing current customers to purchase something immediately,
* adding advertisements to e-mails sent by other companies to their customers, and
* sending e-mails over the Internet, as e-mail did and does exist outside the Internet (e.g., network e-mail and FIDO).

Researchers estimate that United States firms alone spent US $400 million on e-mail marketing in 2006.[1]

Comparison to traditional mail

There are both advantages and disadvantages to using e-mail marketing in comparison to traditional advertising mail.
[edit] Advantages

E-mail marketing (on the Internet) is popular with companies for several reasons:

* An exact return on investment can be tracked ("track to basket") and has proven to be high when done properly. E-mail marketing is often reported as second only to search marketing as the most effective online marketing tactic.[2]
* Advertisers can reach substantial numbers of e-mail subscribers who have opted in (i.e., consented) to receive e-mail communications on subjects of interest to them.
* Over half of Internet users check or send e-mail on a typical day.[3]
* E-mail is popular with digital marketers, rising an estimated 15% in 2009 to £292m in the UK.[4]
* E-mail allows marketers to reach out to consumers with personalized, relevant, dynamic messages.
* Transactional e-mails allow businesses to respond automatically to important consumer events like purchases or shop-cart abandonment.

[edit] Disadvantages

A report issued by the e-mail services company Return Path, as of mid-2008 e-mail deliverability is still an issue for legitimate marketers. According to the report, legitimate e-mail servers averaged a delivery rate of 56%; twenty percent of the messages were rejected, and eight percent were filtered.[5]

Companies considering the use of an e-mail marketing program must make sure that their program does not violate spam laws such as the United States' Controlling the Assault of Non-Solicited Pornography and Marketing Act (CAN-SPAM),[6] the European Privacy and Electronic Communications Regulations 2003, or their Internet service provider's acceptable use policy.
[edit] Opt-in e-mail advertising

Opt-in e-mail advertising, or permission marketing, is a method of advertising via e-mail whereby the recipient of the advertisement has consented to receive it. This method is one of several developed by marketers to eliminate the disadvantages of e-mail marketing.[7]

Opt-in e-mail marketing may evolve into a technology that uses a handshake protocol between the sender and receiver.[7] This system is intended to eventually result in a high degree of satisfaction between consumers and marketers. If opt-in e-mail advertising is used, the material that is e-mailed to consumers will be "anticipated". It is assumed that the consumer wants to receive it, which makes it unlike unsolicited advertisements sent to the consumer. Ideally, opt-in e-mail advertisements will be more personal and relevant to the consumer than untargeted advertisements.

A common example of permission marketing is a newsletter sent to an advertising firm's customers. Such newsletters inform customers of upcoming events or promotions, or new products.[8] In this type of advertising, a company that wants to send a newsletter to their customers may ask them at the point of purchase if they would like to receive the newsletter.

With a foundation of opted-in contact information stored in their database, marketers can send out promotional materials automatically -- known as Drip Marketing. They can also segment their promotions to specific market segments.[9]
[edit] Legal requirements

In 2002 the European Union introduced the Directive on Privacy and Electronic Communications. Article 13 of the Directive prohibits the use of email addresses for marketing purposes. The Directive establishes the opt-in regime, where unsolicited emails may be sent only with prior agreement of the recipient.

The directive has since been incorporated into the laws of member states. In the UK it is covered under the Privacy and Electronic Communications (EC Directive) Regulations 2003[10] and applies to all organisations that send out marketing by some form of electronic communication.

The CAN-SPAM Act of 2003 authorizes a US $16,000 penalty per violation for spamming each individual recipient. Therefore, many commercial e-mail marketers within the United States utilize a service or special software to ensure compliance with the Act. A variety of older systems exist that do not ensure compliance with the Act. To comply with the Act's regulation of commercial e-mail, services typically require users to authenticate their return address and include a valid physical address, provide a one-click unsubscribe feature, and prohibit importing lists of purchased addresses that may not have given valid permission.

In addition to satisfying legal requirements, e-mail service providers (ESPs) began to help customers establish and manage their own e-mail marketing campaigns. The service providers supply e-mail templates and general best practices, as well as methods for handling subscriptions and cancellations automatically. Some ESPs will provide insight/assistance with deliverability issues for major email providers. They also provide statistics pertaining to the number of messages received and opened, and whether the recipients clicked on any links within the messages.

The CAN-SPAM Act was recently updated with some new regulations[clarification needed] that went into effect on July 7, 2008.